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After a group of biologists discovers a huge network of unexplored caves in Romania and, believing it to be an undisturbed eco-system that has produced a new species, they hire the best American team of underwater cave explorers in the world. While exploring deeper into the underwater caves, a rockslide blocks their exit, and they soon discover a larger carnivorous creature has added them to its food chain.
Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity’s final stand against the undead. Now, she must return to where the nightmare began – The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.